Tetrahydrofuran → 5-Chloro-2-methoxy-4-(methylamino)-N-[2-(1-pyrrolidinyl-methyl)-1-azabicyclo[2.2.2]oct-3-yl]benzamide

HRID 92024Notes

Reaction equation

HRID 92024 reaction equation
[C:15]([n:16]1[cH:17][cH:18][n:19][cH:20]1)([n:21]1[cH:22][cH:23][n:24][cH:25]1)=[O:26].[Cl:1][c:2]1[c:3]([NH:13][CH3:14])[cH:4][c:5]([O:11][CH3:12])[c:6]([C:7](=[O:8])[OH:9])[cH:10]1.[N:27]1([CH2:32][CH:33]2[N:34]3[CH2:35][CH2:36][CH:37]([CH:38]2[NH2:39])[CH2:40][CH2:41]3)[CH2:28][CH2:29][CH2:30][CH2:31]1.[O:42]1[CH2:43][CH2:44][CH2:45][CH2:46]1>>[Cl:1][c:2]1[c:3]([NH:13][CH3:14])[cH:4][c:5]([O:11][CH3:12])[c:6]([C:7](=[O:9])[NH:39][CH:38]2[CH:33]([CH2:32][N:27]3[CH2:28][CH2:29][CH2:30][CH2:31]3)[N:34]3[CH2:35][CH2:36][CH:37]2[CH2:40][CH2:41]3)[cH:10]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 682631,1'-CarbonyldiimidazoleHCID 116942165-Chloro-2-methoxy-4-(methylamino)benzoic acidHCID 191084192-(1-Pyrrolidinylmethyl)-1-azabicyclo[2.2.2]octan-3-amine

Product 1

HCID 191083915-Chloro-2-methoxy-4-(methylamino)-N-[2-(1-pyrrolidinyl-methyl)-1-azabicyclo[2.2.2]oct-3-yl]benzamide

Sources & evidence

ORD record
ord-58e1b7ce7b14463e9402eb2fe2d5b3f3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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