反应详情

温度

0 °C

A solution of 3-chloroisoquinoline-8-carboxylic acid (0.5 g, 1.803 mmol) in THF (18.03 ml) at 0° C. was treated with BH3.THF (5.41 ml, 5.41 mmol). After stirring for 2 hours at 0° C., 1N NaOH was added. The reaction was stirred for 30 minutes then diluted with EtOAc and the layers were separated. Aqueous layer was washed with EtOAc three times. All combined organic layers were washed with brine, then dried with sodium sulfate. Filtered and concentrated in vacuo. Purified by silica gel chromatography (0-100% EtOAc in hexane) to yield (3-chloroisoquinolin-8-yl)methanol.

1. stirringThe reaction was stirred for 30 minutes
2. customthe layers were separated
3. washAqueous layer was washed with EtOAc three times
4. washAll combined organic layers were washed with brine
5. dry with materialdried with sodium sulfate
6. filtrationFiltered
7. concentrationconcentrated in vacuo
8. customPurified by silica gel chromatography (0-100% EtOAc in hexane)