Sodium Bicarbonate → HCID 86683160, compound

HRID 920945Notes

Reaction equation

HRID 920945 reaction equation
[ClH:1].[N:2]1[CH:7]=[C:6]([C:8]2[CH:9]=[CH:10][CH:11]=[C:12]3[C:17]=2[C:16](=[O:18])[N:15]([CH:19]2[CH2:21][CH:20]2[C:22]2[CH:31]=[CH:30][C:29]4[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=4)[N:23]=2)[CH:14]=[CH:13]3)[CH:5]=[N:4][CH:3]=1.C(=O)([O-])O.[Na+]>C(Cl)Cl>[Cl:1][C:13]1[C:12]2[C:17](=[C:8]([C:6]3[CH:5]=[N:4][CH:3]=[N:2][CH:7]=3)[CH:9]=[CH:10][CH:11]=2)[C:16](=[O:18])[N:15]([CH:19]2[CH2:21][CH:20]2[C:22]2[CH:31]=[CH:30][C:29]3[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=3)[N:23]=2)[CH:14]=1

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 86683161HCID 86683161, compound

Product 1

HCID 86683160HCID 86683160, compoundYield 7.89%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Anti (+8-(pyrimidin-5-yl)-2-(2-(quinolin-2-yl)cyclopropyl)isoquinolin-1(2H)-one hydrochloride from example 240b was mixed with sodium hydrogencarbonate solution and DCM. The phases were separated and the organic phase dried. Purification by column chromatography (DCM/methanol) gave the title compound (7.89% yield) as white solid. LC-MS: m/e=425.1

Workup

  1. customThe phases were separated
  2. customthe organic phase dried
  3. customPurification by column chromatography (DCM/methanol)

Sources & evidence

ORD record
ord-6b4ec4da598441929008b2f82bc640cd
Source dataset
uspto-grants-2016_03
Patent number
US09273068B2

Reaction notes

Loading…