Potassium Carbonate → HCID 68011897, compound

HRID 920986Notes

Reaction equation

HRID 920986 reaction equation
Cl.[CH3:2][N:3]([CH3:19])[C:4]([C:6]1[N:7]=[C:8]([C:15]([F:18])([F:17])[F:16])[N:9]2[CH2:14][CH2:13][NH:12][CH2:11][C:10]=12)=[O:5].C(=O)([O-])[O-].[K+].[K+]>C(OCC)(=O)C>[CH3:2][N:3]([CH3:19])[C:4]([C:6]1[N:7]=[C:8]([C:15]([F:18])([F:16])[F:17])[N:9]2[CH2:14][CH2:13][NH:12][CH2:11][C:10]=12)=[O:5]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 86685647HCID 86685647, compound

Product 1

HCID 68011897HCID 68011897, compoundYield 95.3%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

N,N-dimethyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro imidazo[1,5-a]pyrazine-1-carboxamide hydrochloride 22b (234 mg, 0.80 mmol) was dissolved in 10 mL of ethyl acetate, followed by addition of potassium carbonate (10 g, 72 mmol). After stirring for 4 hours, the reaction mixture was filtered and the filtrate was concentrated under reduced pressure to obtain crude N,N-dimethyl-3-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide 22c (200 mg) as a light yellow solid. The product was used directly in the next reaction without purification.

Workup

  1. filtrationthe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-a87c565a35894a1bbb075e91b9090524
Source dataset
uspto-grants-2016_03
Patent number
US09273052B2

Reaction notes

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