Potassium Carbonate → HCID 86668816, compound

HRID 921408Notes

Reaction equation

HRID 921408 reaction equation
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[CH:4][N:3]=1.[CH3:9][P:10]([C:13]1[CH:19]=[CH:18][C:16]([NH2:17])=[C:15]([S:20]([CH:23]([CH3:25])[CH3:24])(=[O:22])=[O:21])[CH:14]=1)([CH3:12])=[O:11].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[Cl:8][C:6]1[N:5]=[CH:4][N:3]=[C:2]([NH:17][C:16]2[CH:18]=[CH:19][C:13]([P:10]([CH3:12])([CH3:9])=[O:11])=[CH:14][C:15]=2[S:20]([CH:23]([CH3:25])[CH3:24])(=[O:22])=[O:21])[CH:7]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 709434,6-DichloropyrimidineHCID 67052708HCID 67052708, compound

Product 1

HCID 86668816HCID 86668816, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 4,6-dichloropyrimidine (1.31 mmol) in 1 mL of DMF is added 4-(dimethylphosphoryl)-2-(propan-2-ylsulfonyl)aniline: (1.31 mmol) and potassium carbonate (0.217 g, 1.57 mmol). The mixture is heated at 110° C. until formation of the desired compound. The reaction mixture is basified with saturated sodium bicarbonate solution. The suspension is filtered and washed with ethyl acetate.

Sources & evidence

ORD record
ord-e339f431ed9d41eb88cf7fe737c3257c
Source dataset
uspto-grants-2016_03
Patent number
US09273077B2

Reaction notes

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