Triethylamine → HCID 86668819, compound

HRID 921435Notes

Reaction equation

HRID 921435 reaction equation
Cl[C:2]1[N:7]=[C:6]([Cl:8])[N:5]=[C:4]([NH:9][C:10]2[CH:15]=[CH:14][C:13]([P:16]([CH3:19])([CH3:18])=[O:17])=[CH:12][CH:11]=2)[N:3]=1.C(N(CC)CC)C.[C:27]12([CH2:37][NH2:38])[CH2:36][CH:31]3[CH2:32][CH:33]([CH2:35][CH:29]([CH2:30]3)[CH2:28]1)[CH2:34]2>C(O)C>[Cl:8][C:6]1[N:5]=[C:4]([NH:9][C:10]2[CH:15]=[CH:14][C:13]([P:16]([CH3:19])([CH3:18])=[O:17])=[CH:12][CH:11]=2)[N:3]=[C:2]([NH:38][CH2:37][C:27]23[CH2:36][CH:31]4[CH2:30][CH:29]([CH2:35][CH:33]([CH2:32]4)[CH2:34]2)[CH2:28]3)[N:7]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 86625Tricyclo(3.3.1.13,7)dec-1-ylmethylamineHCID 86668818HCID 86668818, compound

Product 1

HCID 86668819HCID 86668819, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 4,6-dichloro-N-[4-(dimethylphosphoryl)phenyl]-1,3,5-triazin-2-amine (0.072 mmol) in 1.5 mL of ethanol is added 10 L of triethylamine and 1-(1-adamantyl)-methanamine (7.2 mg, 0.072 mmol). The mixture can be microwaved at 120 degrees for 20 minutes. The reaction mixture is filtered through a syringe filter and purified by prep-HPLC.

Workup

  1. customThe mixture can be microwaved at 120 degrees for 20 minutes
  2. filtrationThe reaction mixture is filtered through a syringe
  3. filtrationfilter
  4. custompurified by prep-HPLC

Sources & evidence

ORD record
ord-6c4a84ecc67f4138a5bf984546c6e0b8
Source dataset
uspto-grants-2016_03
Patent number
US09273077B2

Reaction notes

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