Potassium Carbonate → 3-Chloro-4-{3-isopropyl-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzamide

HRID 921559Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[N:10]1[C:14]2=[N:15][CH:16]=[CH:17][C:18](Cl)=[C:13]2[C:12]([CH:20]([CH3:22])[CH3:21])=[N:11]1)[C:5]#[N:6].C(=O)([O-])[O-:24].[K+].[K+].Cl.[CH3:30][N:31]1[CH:35]=[C:34]([C:36]2[N:37]=[CH:38][NH:39][CH:40]=2)[CH:33]=[N:32]1>CS(C)=O.C(Cl)(Cl)Cl.[Cu]=O>[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[N:10]1[C:14]2=[N:15][CH:16]=[CH:17][C:18]([N:39]3[CH:40]=[C:36]([C:34]4[CH:33]=[N:32][N:31]([CH3:30])[CH:35]=4)[N:37]=[CH:38]3)=[C:13]2[C:12]([CH:20]([CH3:22])[CH3:21])=[N:11]1)[C:5]([NH2:6])=[O:24]

Participants

Conditions

Temperature: 120 °C

Procedure

Compound (99a) (0.18 g) was dissolved in DMSO (2.1 mL), and potassium carbonate (0.3 g), copper(II) oxide (nanopowder) (0.086 g), and 4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazole hydrochloride (0.13 g) were added to the resulting solution, followed by stirring at 120° C. for 48 hr. The reaction solution was diluted with chloroform, and insoluble matters were filtered by celite. The solvent was distilled away, and the residue was purified by neutral silica gel column chromatography (chloroform/methanol) to obtain compound (99) (0.045 g, 18%) as a white solid.

Workup

filtrationwere filtered by celite
distillationThe solvent was distilled away
customthe residue was purified by neutral silica gel column chromatography (chloroform/methanol)

Sources & evidence

ORD record: ord-9ce96854abda4220813b9dd2127c9250
Source dataset: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09273045B2

Reaction notes

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