反应详情

After dissolving N-cyclopropylmethyl-N-[7-(2-methoxy-4,6-dimethylphenyl)-2-(methylsulfanyl)pyrazolo[1,5-a]pyridin-3-yl]-N-[(2-methoxy-3-pyridyl)methyl]amine (63 mg) in ethanol (1 mL), a 4 N hydrochloric acid/ethyl acetate solution (1 mL) was added at room temperature and the mixture was heated to reflux for 3 hours. Saturated aqueous sodium hydrogencarbonate was added to the reaction mixture for neutralization while cooling on ice, and extraction was performed with ethyl acetate. The obtained organic layer was washed with water and dried over magnesium sulfate, and the solvent was distilled off under reduced pressure. The obtained residue was purified by silica gel column chromatography (ethyl acetate) to obtain the title compound (49 mg) as white crystals.

1. temperaturethe mixture was heated
2. temperatureto reflux for 3 hours
3. temperaturewhile cooling on ice, and extraction
4. washThe obtained organic layer was washed with water
5. dry with materialdried over magnesium sulfate
6. distillationthe solvent was distilled off under reduced pressure
7. customThe obtained residue was purified by silica gel column chromatography (ethyl acetate)