反应详情

3.40 g (16.8 mmol) of the compound from Example 8A were dissolved in 170 ml of tetrahydrofuran, 1.01 g (25.2 mmol) of sodium hydride (60% in paraffin oil) were added and the mixture was stirred at room temperature for 0.5 hour. 3.58 g (25.2 mmol) of iodomethane were then added, and the reaction mixture was stirred at room temperature for two hours. 3.58 g (25.2 mmol) of iodomethane were then added, and the reaction mixture was stirred at room temperature for two hours. Water was added, the mixture was extracted repeatedly with ethyl acetate and the combined organic phases were dried over sodium sulphate, filtered and concentrated. This gave 3.35 g (92% of theory) of the title compound.

1. stirringthe reaction mixture was stirred at room temperature for two hours
2. stirringthe reaction mixture was stirred at room temperature for two hours
3. extractionthe mixture was extracted repeatedly with ethyl acetate
4. dry with materialthe combined organic phases were dried over sodium sulphate
5. filtrationfiltered
6. concentrationconcentrated