反应详情

To a 250 mL 3-necked RB flask fitted with magnetic stirrer was charged with 5-[1-(4-hydroxyphenyl)but-2-yn-1-yl]-2,2-dimethyl-1,3-dioxane-4,6-dione (5.8 g, 20.13 mmol) in diethyl ketone was added water (13 mL), the reaction mixture was heated to refluxed for 48 h. The RM was acidified with 1N HCl and extracted with ethyl acetate. The organic layer was washed with water, dried over anhydrous sodium sulphat. Finally removal of solvent under reduced pressure to obtain the product (4.11 g, yield: 100.0%).

1. customTo a 250 mL 3-necked RB flask fitted with magnetic stirrer
2. temperaturethe reaction mixture was heated
3. temperatureto refluxed for 48 h
4. extractionextracted with ethyl acetate
5. washThe organic layer was washed with water
6. dry with materialdried over anhydrous sodium sulphat
7. customFinally removal of solvent under reduced pressure