HCID 59760132, compound → HCID 23136325, compound

HRID 922273Notes

Reaction equation

HRID 922273 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[C:5]([F:10])=[CH:4][C:3]=1/[CH:11]=[CH:12]/[C:13]([O:15][CH2:16][CH3:17])=[O:14]>[Pd].C(OCC)(=O)C>[F:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[C:5]([F:10])=[CH:4][C:3]=1[CH2:11][CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14]

Participants

4

Reactant 1

HCID 59760132HCID 59760132, compound

Product 1

HCID 23136325HCID 23136325, compoundYield 80%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

To a 500 mL parr shaker flask was charged with Ethyl (2E)-3-(2,5-difluoro-4-methoxyphenyl)prop-2-enoate (0.1 g, 0.41 mmol), ethyl acetate (5 mL). To the reaction mixture was added 10% Pd—C (20%) and kept for hydrogenation using bladder 1 h. After completion of the reaction, the reaction mixture was filtered through celite, washed thoroughly with ethyl acetate (20 mL) and concentrated to distill off the solvent. The product was obtained as brown solid (0.080 g, yield: 80.0%).

Workup

  1. customAfter completion of the reaction
  2. filtrationthe reaction mixture was filtered through celite
  3. washwashed thoroughly with ethyl acetate (20 mL)
  4. concentrationconcentrated
  5. distillationto distill off the solvent

Sources & evidence

ORD record
ord-048184bf802b41beb1563596a680be64
Source dataset
uspto-grants-2016_03
Patent number
US09278915B2

Reaction notes

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