6-Methoxypyridine-3-carbaldehyde → HCID 178519721, compound

HRID 922302Notes

Reaction equation

HRID 922302 reaction equation
C[O:2][C:3]1[N:8]=[CH:7][C:6]([CH:9]=[O:10])=[CH:5][CH:4]=1>Cl>[OH:2][C:3]1[N:8]=[CH:7][C:6]([CH:9]=[O:10])=[CH:5][CH:4]=1

Participants

3

Reactant 1

HCID 33645766-Methoxypyridine-3-carbaldehyde

Product 1

HCID 178519721HCID 178519721, compoundYield 37%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
100 °C

Procedure

To A 100 mL RB was charged with 6-methoxypyridine-3-carbaldehyde (1 g, 7 mmol) was added 3N HCl (20 mL) and then refluxed it at 100° C. for 12 h. RM was cooled slowly to RT. Solid was obtained up on cooling. It was filtered off on Buchner flask and dried under line vacuum to obtain the title compound as white crystals (0.3 g, Yield: 37%)

Workup

  1. temperatureRM was cooled slowly to RT
  2. customSolid was obtained up
  3. temperatureon cooling
  4. filtrationIt was filtered off on Buchner flask
  5. customdried under line vacuum

Sources & evidence

ORD record
ord-bbee364fc8544db4aa7de7e47853ba96
Source dataset
uspto-grants-2016_03
Patent number
US09278915B2

Reaction notes

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