Acetic Acid → HCID 20213340, compound

HRID 922310Notes

Reaction equation

HRID 922310 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][C:12](/[CH:15]=[CH:16]/[C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.C(O)(=O)C>C(OCC)(=O)C>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:11][CH:10]=2)=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 86695790HCID 86695790, compound

Product 1

HCID 20213340HCID 20213340, compoundYield 71.4%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of ethyl (2E)-3-(4′-methoxybiphenyl-4-yl)prop-2-enoate (1 g, 3.5 mmol) in ethyl acetate was added acetic acid and degassed well with argon and added palladium carbon (100 mg) and stirred under hydrogen for overnight, TLC shows a new spot, RM filtered through celite and washed with ethyl acetate and concentrated to afford white solid (0.7 g, Yield: 71.4%).

Workup

  1. customdegassed well with argon
  2. additionadded palladium carbon (100 mg)
  3. filtrationfiltered through celite
  4. washwashed with ethyl acetate
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-bfd2c430dc6540d3a2476094ca817fe8
Source dataset
uspto-grants-2016_03
Patent number
US09278915B2

Reaction notes

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