反应详情

To a 100 mL RB flask fitted with magnetic stirrer was charged 12 mL of DMF to the stirred solvent was added K2CO3 (2.2 g, 16 mmol), 4-methoxyphenol (1 g, 8 mmol) and ethyl bromoacetate (1.1 mL, 9.6 mmol) Then the reaction mixture was Stirred at RT for 5 h. After completion of the reaction (reaction monitored by TLC), reaction mixture was concentrated and extracted with ethyl acetate. Then the organic layer was dried over anhydrous Na2SO4. Solvent was removed under reduced pressure to get the compound (2 g, Yield: 90%).

1. customTo a 100 mL RB flask fitted with magnetic stirrer
2. customAfter completion of the reaction (reaction monitored by TLC), reaction mixture
3. concentrationwas concentrated
4. extractionextracted with ethyl acetate
5. dry with materialThen the organic layer was dried over anhydrous Na2SO4
6. customSolvent was removed under reduced pressure