反应详情

温度

80 °C

A mixture of 6-bromopicolinaldehyde (5, 1.00 g, 5.38 mmol) and N-isopropylpiperazine-1-carboxamide (4, 1.10 g, 6.45 mmol) in N,N-dimethylacetamide (20 mL) was treated with K2CO3 (2.23 g, 16.1 mmol) and heated at 80° C. for 18 h. The mixture was cooled to room temperature and concentrated. The residue was purified by silica gel chromatography eluting with hexanes to 100% EtOAc to 4:1 EtOAc/MeOH to afford the title compound (0.35 g, 24%) as an impure yellow solid: Multimode MS m/z 172 [M+H]+.

1. temperatureThe mixture was cooled to room temperature
2. concentrationconcentrated
3. customThe residue was purified by silica gel chromatography
4. washeluting with hexanes to 100% EtOAc to 4:1 EtOAc/MeOH