Benzaldehyde → HCID 86729843, compound

HRID 922506Notes

Reaction equation

HRID 922506 reaction equation
[ClH:1].C(OCC)(=O)C.C([NH:15][C@@H:16]1[CH2:18][C@H:17]1[C:19]1[CH:24]=[CH:23][C:22]([NH:25][C:26](=[O:41])[C:27]2[CH:32]=[CH:31][CH:30]=[C:29]([O:33][CH2:34][C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=3)[CH:28]=2)=[CH:21][CH:20]=1)C1C=CC=CC=1.C(=O)C1C=CC=CC=1>>[ClH:1].[NH2:15][C@@H:16]1[CH2:18][C@H:17]1[C:19]1[CH:24]=[CH:23][C:22]([NH:25][C:26](=[O:41])[C:27]2[CH:32]=[CH:31][CH:30]=[C:29]([O:33][CH2:34][C:35]3[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=3)[CH:28]=2)=[CH:21][CH:20]=1

Participants

4

Reactant 3

HCID 240BenzaldehydeHCID 21866389Hydrogen chloride-ethyl acetateHCID 86729845HCID 86729845, compound

Product 1

HCID 86729843HCID 86729843, compound

Procedure

By a method similar to Example 1, Step C, 4N hydrochloric acid/ethyl acetate solution was added to N-{4-[trans-2-(benzylamino)cyclopropyl]phenyl}-3-(benzyloxy)benzamide obtained from N-[4-(trans-2-aminocyclopropyl)phenyl]-3-(benzyloxy)benzamide hydrochloride (109 mg) and benzaldehyde (29.3 μL), and the resulting solid was collected by filtration to give the title compound (96.1 mg).

Sources & evidence

ORD record
ord-a9a668dcd73a4e7bac4c8dd75a3ff1d2
Source dataset
uspto-grants-2016_03
Patent number
US09278931B2

Reaction notes

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