Potassium Carbonate → HCID 89654198, compound

HRID 922562Notes

Reaction equation

HRID 922562 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][N:3]=1.Br[CH:10]([CH:12]1[CH2:14][C:13]1([F:16])[F:15])C.C([O-])([O-])=O.[K+].[K+]>C(#N)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:10][CH:12]2[CH2:14][C:13]2([F:16])[F:15])=[CH:4][N:3]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 27628652-Bromo-5-hydroxypyridineHCID 117696598HCID 117696598, compound

Product 1

HCID 89654198HCID 89654198, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
70 °C

Procedure

The mixture of 0.30 g (1.7 mmol) of 2-bromo-5-hydroxypyridine, 0.59 g (3.5 mmol) of 1-bromoethyl-2,2-difluorocyclopropane and 0.60 g (4.3 mmol) of K2CO3 in 10 ml ACN is stirred at 70° C. over night. The reaction mixture is filtered over alumina/activated carbon. The solvent is removed in vacuo.

Workup

  1. filtrationThe reaction mixture is filtered over alumina/activated carbon
  2. customThe solvent is removed in vacuo

Sources & evidence

ORD record
ord-d0f2de82ac274f11b144b6d892f93f6b
Source dataset
uspto-grants-2016_03
Patent number
US09278954B2

Reaction notes

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