反应详情

In 95 ml of toluene, 4.756 g of Compound 2-1 obtained in Production Example 1 was dissolved. To the solution thus obtained, 3.12 ml of triethylamine and 1.76 ml of N-methylimidazole were added, and 3.38 g of 4-toluenesulfonyl chloride was added. The resulting mixture was stirred at room temperature for 100 minutes. After the reaction, water was added to the reaction solution thus obtained, and the organic layer was separated from the suspension. Thereafter, the aqueous layer was extracted with toluene and then blended with the organic layer previously obtained. The resultant organic layer thus obtained was washed with an aqueous solution of 1 mol/l hydrochloric acid and saturated brine and then dried over anhydrous sodium sulfate. The solvent was distilled away, and the residue was then purified by silica gel column chromatography to obtain 5.397 g of Compound 3-1-2.

1. dissolutionwas dissolved
2. customTo the solution thus obtained
3. additionwas added to the reaction solution
4. customthus obtained
5. customthe organic layer was separated from the suspension
6. extractionThereafter, the aqueous layer was extracted with toluene
7. custompreviously obtained
8. customThe resultant organic layer thus obtained
9. washwas washed with an aqueous solution of 1 mol/l hydrochloric acid and saturated brine
10. dry with materialdried over anhydrous sodium sulfate
11. distillationThe solvent was distilled away
12. customthe residue was then purified by silica gel column chromatography