反应详情

L-Threonine (0.50 g, 4.2 mmol) and sodium bicarbonate (1.13 g, 13.4 mmol) were dissolved into water (20 mL) then cooled in an ice bath. Methyl chloroformate (0.36 mL, 4.62 mmol) was dissolved in diethyl ether (2 mL) and added dropwise with vigorous stirring. The solution was stirred at ambient temperature for 5 hours then adjusted to pH 3 with concentrated hydrochloric acid and extracted into ethyl acetate. The organic solution was dried over sodium sulfate, filtered, and concentrated to give 0.12 g of the title compound as a waxy solid.

1. temperaturethen cooled in an ice bath
2. additionadded dropwise with vigorous stirring
3. extractionextracted into ethyl acetate
4. dry with materialThe organic solution was dried over sodium sulfate
5. filtrationfiltered
6. concentrationconcentrated