Trifluoroacetic acid → HCID 59540446, compound

HRID 923426Notes

Reaction equation

HRID 923426 reaction equation
[CH2:1]([N:3]([C@H:7]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[C:8]([O:10]C(C)(C)C)=[O:9])[C:4](=[O:6])[CH3:5])[CH3:2].FC(F)(F)C(O)=O>C(Cl)Cl>[CH2:1]([N:3]([C@H:7]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[C:8]([OH:10])=[O:9])[C:4](=[O:6])[CH3:5])[CH3:2]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59540408HCID 59540408, compound

Product 1

HCID 59540446HCID 59540446, compoundYield 77.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of product from example 122B (81 mg, 0.293 mmol) in CH2Cl2 (3 mL) was added 2,2,2-trifluoroacetic acid (1.5 mL, 0.293 mmol), and the resulting mixture was stirred at rt for 1 hr. The mixture was concentrated in vacuo to give the title compound (50 mg, 77%).

Workup

  1. concentrationThe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-aee99197c8d541ff8024caa0dc533eb8
Source dataset
uspto-grants-2016_03
Patent number
US09278922B2

Reaction notes

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