Hydrochloric Acid → HCID 59540152, compound

HRID 923430Notes

Reaction equation

HRID 923430 reaction equation
[C:1]([O:5][C:6](=[O:23])[C@H:7]([NH:14][CH2:15][CH2:16][CH2:17][C:18]([O:20]CC)=[O:19])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+].Cl>CO>[C:1]([O:5][C:6](=[O:23])[C@H:7]([NH:14][CH2:15][CH2:16][CH2:17][C:18]([OH:20])=[O:19])[C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 59540305HCID 59540305, compound

Product 1

HCID 59540152HCID 59540152, compoundYield 71%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The product of example 128A (480 mg, 1.49 mmol) and NaOH (299 mg, 7.47 mmol) in MeOH (10 mL) was stirred at ambient temperature for 1 hour. The mixture had HCl (1M) added and was extracted with EtOAc. The organic was washed with brine, dried (MgSO4), filtered and concentrated to afford 310 mg (71%) of the title compound. MS (ESI) m/z 294 (M+H)+.

Workup

  1. additionadded
  2. extractionwas extracted with EtOAc
  3. washThe organic was washed with brine
  4. dry with materialdried (MgSO4)
  5. filtrationfiltered
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-7220ea183886436984e3c492035af6cd
Source dataset
uspto-grants-2016_03
Patent number
US09278922B2

Reaction notes

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