HCID 59540096, compound → HCID 59540360, compound

HRID 923432Notes

Reaction equation

HRID 923432 reaction equation
[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][N:3]1[C@H:7]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[C:8]([O:10]C(C)(C)C)=[O:9]>FC(F)(F)C(O)=O>[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][N:3]1[C@H:7]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[C:8]([OH:10])=[O:9]

Participants

3

Reactant 1

HCID 59540096HCID 59540096, compound

Product 1

HCID 59540360HCID 59540360, compoundYield 103%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

The product of example 128C (245 mg, 0.89 mmol) in trifluoroacetic acid (5 mL) was stirred at ambient temperature for 2 hours. The mixture was concentrated to afford 201 mg (100%) of the title compound. MS (ESI) m/z 276 (M+H)+.

Workup

  1. concentrationThe mixture was concentrated

Sources & evidence

ORD record
ord-0020d13a381a40668d4b1850416a6ce0
Source dataset
uspto-grants-2016_03
Patent number
US09278922B2

Reaction notes

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