Trifluoroacetic acid → HCID 118308743, compound

HRID 923465Notes

Reaction equation

HRID 923465 reaction equation
CC1(C)[N:6](C(OC(C)(C)C)=O)[C:5]([CH3:20])([C:14]2[O:15][C:16]([CH3:19])=[N:17][N:18]=2)[CH2:4][O:3]1.[F:22][C:23]([F:28])([F:27])[C:24]([OH:26])=[O:25]>ClCCl>[F:22][C:23]([F:28])([F:27])[C:24]([OH:26])=[O:25].[NH2:6][C:5]([C:14]1[O:15][C:16]([CH3:19])=[N:17][N:18]=1)([CH3:20])[CH2:4][OH:3]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 118308725HCID 118308725, compound

Product 1

HCID 118308743HCID 118308743, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 84 mg of tert-butyl 2,2,4-trimethyl-4-(5-methyl-1,3,4-oxadiazol-2-yl)-1,3-oxazolidine-3-carboxylate in 1.5 ml of dichloromethane was added 500 μl of trifluoroacetic acid, followed by stirring at room temperature for 2 hours. The reaction mixture was concentrated under reduced pressure, methanol was added thereto, and the solvent was evaporated again to obtain 76 mg of 2-amino-2-(5-methyl-1,3,4-oxadiazol-2-yl)propan-1-ol trifluoroacetate.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure, methanol
  2. additionwas added
  3. customthe solvent was evaporated again

Sources & evidence

ORD record
ord-969dd93acc224f1f8f4880279b492d52
Source dataset
uspto-grants-2016_03
Patent number
US09278968B2

Reaction notes

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