反应详情

A mixture of 15-4 (20 mg, 0.032 mmol) in acetic acid (0.3 mL)/water (0.1 mL)/THF (0.1 mL) was stirred at room temperature. After two days, saturated NaHCO3 solution was added and the resulting mixture was extracted with dichloromethane (3×20 mL). The combined dichloromethane solution was dried (Na2SO4), filtered and evaporated. The residue was purified by flash chromatography on silica gel (20% ethyl acetate/hexanes→30% →40%) which gave the title compound (11 mg, 67%).

1. extractionthe resulting mixture was extracted with dichloromethane (3×20 mL)
2. dry with materialThe combined dichloromethane solution was dried (Na2SO4)
3. filtrationfiltered
4. customevaporated
5. customThe residue was purified by flash chromatography on silica gel (20% ethyl acetate/hexanes→30% →40%) which