反应详情

4-Bromobenzaldehyde (3 g, 16.21 mmol) and ethyl cyanoacetate (1.9 ml, 17.84 mmol) in toluene was added piperidine (27 μl) and the reaction mixture was refluxed for 1 hour with a Dean-Stark separator. The solvent was removed under reduced pressure, the residue triturated with warm ethyl acetate, filtered to yield the desired product as a yellow solid (4.03 g, 89% yield). LC/MS: (PS-A2) Rt 3.44.

1. temperaturethe reaction mixture was refluxed for 1 hour with a Dean-Stark separator
2. customThe solvent was removed under reduced pressure
3. customthe residue triturated with warm ethyl acetate
4. filtrationfiltered