反应详情

To a solution of 4-bromobiphenyl (683 mg, 2.9 mmol) in anhydrous THF (5 mL) was added n-BuLi (1.2 mL, 2.9 mmol) dropwise at −78° C. After being stirred at the temperature for 0.5 h, a solution of N-methoxy-N-methyl-2-phenyl-acetamide (prepared following step 1 of Intermediate 4) (500 mg, 2.8 mmol) in anhydrous THF (5 mL) was added via a syringe, and the mixture was stirred at −78° C. for 2 h. The reaction was quenched with saturated NH4Cl aqueous solution, and extracted with EtOAc. The organic layer was dried over Na2SO4, concentrated in vacuo, and purified by column chromatography (PE:EtOAc=20:1) to give 1-(biphenyl-4-yl)-2-phenylethanone (180 mg, yield 24%).

1. stirringthe mixture was stirred at −78° C. for 2 h
2. customThe reaction was quenched with saturated NH4Cl aqueous solution
3. extractionextracted with EtOAc
4. dry with materialThe organic layer was dried over Na2SO4
5. concentrationconcentrated in vacuo
6. custompurified by column chromatography (PE:EtOAc=20:1)