Diethyl Carbonate → HCID 89893995, compound

Temperature

90 °C

(S)-2-(Benzyloxymethyl)oxirane (2.5 g, 15.23 mmol) was added dropwise to hydrazine mono-hydrate (5.44 g, 107 mmol), previously heated at 90° C. The mixture was refluxed for 30 min, under stirring. The excess of hydrazine hydrate was evaporated under vacuum (8 mbar), at 60° C., for 6 h and then at room temperature, under vigorous magnetic stirring, for 18 h. The obtained sticky colourless oil was dissolved in dry methanol (5 mL) and a solution of sodium methoxide (0.5M in MeOH, 4.57 mL, 2.28 mmol) and then diethyl carbonate (2.16 g, 18.27 mmol) were added dropwise. The mixture was refluxed for 4 h 30 min. Solvent was evaporated and the crude purified by flash silica-gel chromatography (DCM/MeOH=75:1) affording the title compound as a yellow oil that solidified (white solid) on standing (2.074 g, 9.33 mmol). Yield=61%.

1. temperatureThe mixture was refluxed for 30 min
2. customThe excess of hydrazine hydrate was evaporated under vacuum (8 mbar), at 60° C., for 6 h
3. dissolutionThe obtained sticky colourless oil was dissolved in dry methanol (5 mL)
4. temperatureThe mixture was refluxed for 4 h 30 min
5. customSolvent was evaporated
6. customthe crude purified by flash silica-gel chromatography (DCM/MeOH=75:1)

ORD record

ord-c8791ff7bb164b13a60a6f894c1ea3c3

Source dataset

uspto-grants-2016_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09284306B2