Isopropylamine → HCID 68207821, compound

HRID 926029Notes

Reaction equation

HRID 926029 reaction equation
Br[CH2:2][C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][CH:12]=1)[C:6]([O:8][CH3:9])=[O:7].[CH:13]([NH2:16])([CH3:15])[CH3:14]>CN(C=O)C>[CH:13]([NH:16][CH2:2][C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][CH:12]=1)[C:6]([O:8][CH3:9])=[O:7])([CH3:15])[CH3:14]

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 517981Methyl 3-(bromomethyl)benzoate

Product 1

HCID 68207821HCID 68207821, compoundYield 66.3%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 2.00 g of methyl 3-(bromomethyl)benzoate, 1.55 g of isopropylamine, and 10 mL of DMF was stirred at room temperature overnight. The reaction mixture was concentrated under reduced pressure and the obtained residue was purified by silica gel column chromatography (chloroform-methanol) to obtain 1.20 g of methyl 3-[(isopropylamino)methyl]benzoate as a colorless solid.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customthe obtained residue was purified by silica gel column chromatography (chloroform-methanol)

Sources & evidence

ORD record
ord-2c702462257945128a21ec24bd175743
Source dataset
uspto-grants-2016_03
Patent number
US09284295B2

Reaction notes

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