Hydrochloric Acid → HCID 89971826, compound

HRID 926231Notes

Reaction equation

HRID 926231 reaction equation
C[O:2][CH:3](OC)[CH2:4][NH:5][C:6](=[O:20])[CH2:7][CH2:8][CH2:9][CH2:10][C@H:11]1[C@@H:19]2[C@@H:14]([NH:15][C:16]([NH:18]2)=[O:17])[CH2:13][S:12]1.Cl>CO>[O:2]=[CH:3][CH2:4][NH:5][C:6](=[O:20])[CH2:7][CH2:8][CH2:9][CH2:10][C@H:11]1[C@@H:19]2[C@@H:14]([NH:15][C:16]([NH:18]2)=[O:17])[CH2:13][S:12]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 88996188HCID 88996188, compound

Product 1

HCID 89971826HCID 89971826, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
25 °C

Procedure

N-(2,2-Dimethoxyethyl)biotinamide (9, 280 mg, 850 μmol) was dissolved in MeOH (2 mL) and conc. HCl (0.5 mL) was added to the solution, which was allowed to stir for 1 h at 25° C. The reaction mixture was evaporated to dryness under reduced pressure to yield the aldehyde, the total amount of which was used without further purification in the preparation of 10.

Workup

  1. customThe reaction mixture was evaporated to dryness under reduced pressure

Sources & evidence

ORD record
ord-fd5d492bff014f28b405f270dba3b36d
Source dataset
uspto-grants-2016_03
Patent number
US09284343B2

Reaction notes

Loading…