反应详情

温度

100 °C

100-2. A mixture of 9-acetyl-3,4,7,8-tetrahydro-[1,4]diazepino[7,1-a]isoquinoline-2,5-dione (200 mg, 0.74 mmol) in DMF (1.0 mL) was treated with DMF-DMA (0.12 mL, 0.89 mmol) and stirred at 100° C. for 1 h. The mixture was concentrated in vacuo and the crude product obtained was purified by flash chromatography (SiO2, DCM/MeOH 98:2 to 85:15) to give the title compound (135 mg) as a beige solid. UPLC-MS: MS 236.2 (M+H+), UPLC rt 0.54 min.

1. concentrationThe mixture was concentrated in vacuo
2. customthe crude product obtained
3. customwas purified by flash chromatography (SiO2, DCM/MeOH 98:2 to 85:15)