Lithium iodide → HCID 117902180, compound

HRID 926682Notes

Reaction equation

HRID 926682 reaction equation
[CH:1]12[CH2:16][O:15][CH2:14][CH:13]1[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH:4]1[CH:2]2[O:3]1.[I-].[Li+]>>[CH2:14]1[CH:13]2[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][C:2](=[O:3])[CH:1]2[CH2:16][O:15]1

Participants

3

Reactant 2

HCID 66321Lithium iodideHCID 117902423HCID 117902423, compound

Product 1

HCID 117902180HCID 117902180, compoundYield 53%

Conditions

Temperature
200 °C

Procedure

3,15-Dioxa-tricyclo[11.3.0.0*2,4*]hexadecane from Step 1 (260 g, 1.16 mol) was mixed with lithium iodide (2.5 g, 18.7 mmol) and heated to 200° C. for 8 hours. The reaction was then cooled down and washed with water (500 mL). The crude was distilled to provide dodecahydro-2-oxa-cyclopentacyclododecen-4-one (138 g, ˜53% yield).

Workup

  1. temperatureThe reaction was then cooled down
  2. washwashed with water (500 mL)
  3. distillationThe crude was distilled

Sources & evidence

ORD record
ord-fc7027f01e6946ce9bc15a763e5c924f
Source dataset
uspto-grants-2016_03
Patent number
US09289366B2

Reaction notes

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