Hydrochloric Acid → HCID 89618838, compound

HRID 926707Notes

Reaction equation

HRID 926707 reaction equation
C(OC([NH:8][C:9]1([C:39]([OH:41])=[O:40])[CH2:14][CH2:13][N:12]([C:15]([C:17]2[CH:18]=[N:19][N:20]3[CH:25]=[CH:24][C:23]([N:26]4[CH2:30][CH2:29][CH2:28][C@@H:27]4[C:31]4[CH:36]=[C:35]([F:37])[CH:34]=[CH:33][C:32]=4[F:38])=[CH:22][C:21]=23)=[O:16])[CH2:11][CH2:10]1)=O)(C)(C)C.[ClH:42]>O1CCOCC1>[ClH:42].[NH2:8][C:9]1([C:39]([OH:41])=[O:40])[CH2:14][CH2:13][N:12]([C:15]([C:17]2[CH:18]=[N:19][N:20]3[CH:25]=[CH:24][C:23]([N:26]4[CH2:30][CH2:29][CH2:28][C@@H:27]4[C:31]4[CH:36]=[C:35]([F:37])[CH:34]=[CH:33][C:32]=4[F:38])=[CH:22][C:21]=23)=[O:16])[CH2:11][CH2:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 89618808HCID 89618808, compound

Product 1

HCID 89618838HCID 89618838, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
27.5 °C

Procedure

(R)-4-((tert-butoxycarbonyl)amino)-1-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)piperidine-4-carboxylic acid (100 mg, 0.17 mmol) added to 4N HCl in Dioxane (5 mL) was stirred at 20-35° C. for 3 h. The reaction mixture was concentrated under reduced pressure to afford crude. The crude obtained was washed with diethyl ether and dried to afford 58 mg of the title compound as a pale brown solid.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customto afford crude
  3. customThe crude obtained
  4. washwas washed with diethyl ether
  5. customdried

Sources & evidence

ORD record
ord-45309b96f2764ca5b96a8f5e544318f8
Source dataset
uspto-grants-2016_03
Patent number
US09289419B2

Reaction notes

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