Hydrochloric Acid → HCID 66672546, compound

HRID 926720Notes

Reaction equation

HRID 926720 reaction equation
[ClH:1].[CH3:2][S:3]([N:6]1[CH2:10][CH2:9][C@H:8]([NH:11]C(=O)OC(C)(C)C)[CH2:7]1)(=[O:5])=[O:4]>>[ClH:1].[CH3:2][S:3]([N:6]1[CH2:10][CH2:9][C@H:8]([NH2:11])[CH2:7]1)(=[O:5])=[O:4]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 589598791,1-Dimethylethyl N-[(3S)-1-(methylsulfonyl)-3-pyrrolidinyl]carbamate

Product 1

HCID 66672546HCID 66672546, compound

Procedure

4M HCl solution (in Dioxane) (2 mL) and (S)-tert-butyl (1-(methylsulfonyl)pyrrolidin-3-yl)carbamate (200 mg, 0.99 mmol) was stirred at 20-35° C. for 2 h. The solid precipitate thus obtained was filtered, washed with hexane and dried to afford 120 mg of the title compound.

Workup

  1. customThe solid precipitate thus obtained
  2. filtrationwas filtered
  3. washwashed with hexane
  4. customdried

Sources & evidence

ORD record
ord-44e1e5ff0432417286e55ac956737ac5
Source dataset
uspto-grants-2016_03
Patent number
US09289419B2

Reaction notes

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