反应详情

NaHCO3 (1.09 g, 12.97 mmol) in water (5 mL) was added to a stirred solution of 2-aminoacetonitrile sulfate (1.0 g, 6.48 mmol) in 1,4-Dioxane (10 mL) at 0-5° C. followed by addition of Benzylchloroformate (1.3 g, 1.11 mL, 7.78 mmol) and stirring was continued at 20-35° C. for 15 h. Reaction mixture was diluted with DCM and washed it with water, dried over anhydrous sodium sulphate and concentrated under reduced pressure to afford the crude, which was purified by Column chromatography (using Silica gel 60-120 and 10% MeOH in DCM as eluent) to afford 700 mg of the title compound.

1. customReaction mixture
2. washwashed it with water
3. dry with materialdried over anhydrous sodium sulphate
4. concentrationconcentrated under reduced pressure
5. customto afford the crude, which
6. customwas purified by Column chromatography (using Silica gel 60-120 and 10% MeOH in DCM as eluent)