HCID 90203466, compound → HCID 76071554, compound

HRID 927035Notes

Reaction equation

HRID 927035 reaction equation
[CH3:1][O:2][C:3](=[O:31])[C:4]1[CH:9]=[CH:8][C:7]([CH2:10][O:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]3[C:22]([NH:23]C(OC(C)(C)C)=O)=[CH:21][O:20][N:19]=3)=[CH:14][CH:13]=2)=[CH:6][CH:5]=1>Cl.O1CCOCC1>[CH3:1][O:2][C:3](=[O:31])[C:4]1[CH:9]=[CH:8][C:7]([CH2:10][O:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]3[C:22]([NH2:23])=[CH:21][O:20][N:19]=3)=[CH:14][CH:13]=2)=[CH:6][CH:5]=1

Participants

4

Reactant 1

HCID 90203466HCID 90203466, compound

Product 1

HCID 76071554HCID 76071554, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

4-[4-(4-tert-Butoxycarbonylamino-isoxazol-3-yl)-phenoxymethyl]-benzoic acid methyl ester was suspended in 4N hydrochloric acid in dioxane (20 volumes) and stirred at rt for 16 hours (reaction progress monitored by TLC). The solvent was removed by evaporation to give 4-[4-(4-amino-isoxazol-3-yl)-phenoxymethyl]-benzoic acid methyl ester as the hydrochloride salt, which required no further purification. M+1=325.2

Workup

  1. custom(reaction progress monitored by TLC)
  2. customThe solvent was removed by evaporation

Sources & evidence

ORD record
ord-14dfbdcd758d480d9be635a261eac488
Source dataset
uspto-grants-2016_03
Patent number
US09290465B2

Reaction notes

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