HCID 90203161, compound → HCID 74763821, compound

HRID 927036Notes

Reaction equation

HRID 927036 reaction equation
C(OC(=O)[NH:7][C:8]1[C:9]([C:13]2[CH:18]=[CH:17][C:16]([O:19][CH2:20][C:21]3[CH:26]=[CH:25][C:24]([S:27]([CH3:30])(=[O:29])=[O:28])=[CH:23][CH:22]=3)=[CH:15][CH:14]=2)=[N:10][O:11][CH:12]=1)(C)(C)C>Cl>[CH3:30][S:27]([C:24]1[CH:23]=[CH:22][C:21]([CH2:20][O:19][C:16]2[CH:15]=[CH:14][C:13]([C:9]3[C:8]([NH2:7])=[CH:12][O:11][N:10]=3)=[CH:18][CH:17]=2)=[CH:26][CH:25]=1)(=[O:28])=[O:29]

Participants

3

Reactant 1

HCID 90203161HCID 90203161, compound

Product 1

HCID 74763821HCID 74763821, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

{3-[4-(4-Methanesulfonyl-benzyloxy)-phenyl]-isoxazol-4-yl}-carbamic acid tert-butyl ester (20.5 mg, 0.046 mmol) was dissolved in a 2M HCl in dioxanes (5 mL, 10 mmol) and stirred at rt until no starting material remained. Removal of volatiles under reduced pressure and workout according to Example 2 provided 3-[4-(4-methanesulfonyl-benzyloxy)-phenyl]-isoxazol-4-ylamine (14.5 mg, 91%). HRMS (M+1)=345.09

Workup

  1. customRemoval of volatiles under reduced pressure and workout

Sources & evidence

ORD record
ord-395710c3d825490c8eabb57293107dc2
Source dataset
uspto-grants-2016_03
Patent number
US09290465B2

Reaction notes

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