Hydrochloric Acid → HCID 76071680, compound

HRID 927054Notes

Reaction equation

HRID 927054 reaction equation
C(OC(=O)[NH:7][C:8]1[C:9]([C:13]2[CH:18]=[CH:17][C:16]([O:19][CH2:20][C:21](=[O:28])[C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[CH:15][CH:14]=2)=[N:10][O:11][CH:12]=1)(C)(C)C.[ClH:30]>O1CCOCC1>[ClH:30].[NH2:7][C:8]1[C:9]([C:13]2[CH:14]=[CH:15][C:16]([O:19][CH2:20][C:21]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[O:28])=[CH:17][CH:18]=2)=[N:10][O:11][CH:12]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 90203755HCID 90203755, compound

Product 1

HCID 76071680HCID 76071680, compoundYield 64%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

{3-[4-(2-Oxo-2-phenyl-ethoxy)-phenyl]-isoxazol-4-yl}-carbamic acid tert-butyl ester (70 mg, 0.18 mmol) was dissolved in dioxane (1 mL) and treated with 4N HCl in dioxane (1 mL, 4 mmol). After stirring overnight the resulting white solid was removed by filtration and washed with hexanes to yield 2-[4-(4-Amino-isoxazol-3-yl)-phenoxy]-1-phenyl-ethanone hydrochloride as a white solid (34 mg, 64%). MH+=295.0

Workup

  1. customwas removed by filtration
  2. washwashed with hexanes

Sources & evidence

ORD record
ord-837c639176894bb58b4f9d5df8030a90
Source dataset
uspto-grants-2016_03
Patent number
US09290465B2

Reaction notes

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