Ethyl Acetate → HCID 178424854, compound

HRID 927142Notes

Reaction equation

HRID 927142 reaction equation
OC1C(=O)NN=C(CCC2C=CC=CC=2)C=1.C([O:24][C:25]1[N:26]=[N:27][C:28]([C:39]#[C:40][C:41]2[CH:46]=[CH:45][C:44]([CH3:47])=[C:43]([F:48])[CH:42]=2)=[CH:29][C:30]=1[O:31]CC1C=CC=CC=1)C1C=CC=CC=1.C(OCC)(=O)C>CO>[F:48][C:43]1[CH:42]=[C:41]([CH2:40][CH2:39][C:28]2[CH:29]=[C:30]([OH:31])[C:25](=[O:24])[NH:26][N:27]=2)[CH:46]=[CH:45][C:44]=1[CH3:47]

Participants

5

Reactant 3

HCID 8857Ethyl AcetateHCID 712702423,4-Bis(benzyloxy)-6-[2-(3-fluoro-4-methylphenyl)ethynyl]pyridazine2×HCID 1785188083-Hydroxy-6-(2-Phenylethyl)pyridazin-4(1h)-One

Product 1

HCID 178424854HCID 178424854, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Prepared by the same method as for 4-hydroxy-6-(2-phenylethyl)pyridazin-3(2H)-one (Example 1) from 3,4-bis(benzyloxy)-6-[2-(3-fluoro-4-methylphenyl)ethynyl]pyridazine (Intermediate 28) except that the solvent mixture used for the hydrogenation was ethyl acetate and methanol (1:1) and the final product was recrystallised from ethyl acetate.

Workup

  1. customthe final product was recrystallised from ethyl acetate

Sources & evidence

ORD record
ord-43267618b00e442ca9f38268303d638f
Source dataset
uspto-grants-2016_03
Patent number
US09290456B2

Reaction notes

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