Ethyl Acetate → HCID 178436267, compound

HRID 927154Notes

Reaction equation

HRID 927154 reaction equation
OC1C(=O)NN=C(CCC2C=CC=CC=2)C=1.C(OC1N=NC(C#CC(C)C)=CC=1OCC1C=CC=CC=1)C1C=CC=CC=1.C([O:51][C:52]1[N:53]=[N:54][C:55]([C:66]([C:68]2[CH:73]=[CH:72][CH:71]=[C:70]([C:74]([F:77])([F:76])[F:75])[CH:69]=2)=[CH2:67])=[CH:56][C:57]=1[O:58]CC1C=CC=CC=1)C1C=CC=CC=1.C(OCC)(=O)C>O1CCCC1>[OH:58][C:57]1[C:52](=[O:51])[NH:53][N:54]=[C:55]([CH:66]([C:68]2[CH:73]=[CH:72][CH:71]=[C:70]([C:74]([F:76])([F:75])[F:77])[CH:69]=2)[CH3:67])[CH:56]=1

Participants

6

Reactant 4

HCID 8857Ethyl AcetateHCID 71269995HCID 71269995, compoundHCID 86677040HCID 86677040, compoundHCID 1785188083-Hydroxy-6-(2-Phenylethyl)pyridazin-4(1h)-One

Product 1

HCID 178436267HCID 178436267, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared by the same method as for 4-hydroxy-6-(2-phenylethyl)pyridazin-3(2H)-one (Example 1) from 3,4-bis(benzyloxy)-6-(3-methylbut-1-ynyl)pyridazine (Intermediate 43) except that the solvent mixture used for the hydrogenation was made up of ethyl acetate and tetrahydrofuran and the product was recrystallised from heptane and MTBE.

Workup

  1. customthe product was recrystallised from heptane and MTBE

Sources & evidence

ORD record
ord-f600611ba16c4ae0a0e5ef84eb02d6eb
Source dataset
uspto-grants-2016_03
Patent number
US09290456B2

Reaction notes

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