反应详情

A solution of (S)-tert-butyl 1-cyclopropyl-3-hydroxy-3-methylbutan-2-ylcarbamate (0.8 g, 3 mmol) in ethyl acetate was saturated with hydrochloride (10 mL) and stirred for 1 h at room temperature. After diluting with water (20 mL), the layers were separated and the water phase was washed with ethyl acetate (20 mL). Then it was adjusted with 1 N NaOH to pH=8˜9 and extracted with methylene chloride (3×20 mL). The combined organic layer was dried over anhydrous sodium sulfate and concentrated to give the title compound as yellow oil (0.3 g, 64%); MS (EI): m/e=144.2 [M+Na]+.

1. customthe layers were separated
2. washthe water phase was washed with ethyl acetate (20 mL)
3. extractionextracted with methylene chloride (3×20 mL)
4. dry with materialThe combined organic layer was dried over anhydrous sodium sulfate
5. concentrationconcentrated