反应详情

Bromoethane (0.1 mL) was added to a mixture of 4-(3-fluorobenzyl)piperidine (Intermediate 180, 0.259 g) and potassium carbonate (0.204 g) in acetonitrile (10 mL). The mixture was stirred for 20 hours then filtered. The filtrate acidified by addition of few drops of 2M HCl and the solution was passed through a SCX-2 column (10 g). The product was eluted with 2M ammonia in methanol and the residue after evaporation was triturated with diethyl ether. The solid was filtered off and the filtrated was concentrated in vacuo to give 1-ethyl-4-(3-fluorobenzyl)piperidine (0.210 g)

1. filtrationthen filtered
2. additionThe filtrate acidified by addition of few drops of 2M HCl
3. washThe product was eluted with 2M ammonia in methanol
4. customthe residue after evaporation
5. customwas triturated with diethyl ether
6. filtrationThe solid was filtered off
7. concentrationthe filtrated was concentrated in vacuo