Trifluoroacetic acid → HCID 178426863, compound

HRID 929103Notes

Reaction equation

HRID 929103 reaction equation
C(O)(C(F)(F)F)=O.[CH3:8][C:9]1[CH:46]=[C:45]([CH3:47])[CH:44]=[CH:43][C:10]=1[O:11][CH2:12][C@H:13]([OH:42])[CH2:14][NH:15][C:16]1[CH:21]=[CH:20][NH:19][C:18](=[O:22])[C:17]=1[C:23]1[NH:34][C:33]2[C:25](=[CH:26][C:27]3[CH2:28][N:29]([CH:36]4[CH2:41][CH2:40][NH:39][CH2:38][CH2:37]4)[C:30](=[O:35])[C:31]=3[CH:32]=2)[N:24]=1.CCN(C(C)C)C(C)C.[C:57](#[N:60])[CH:58]=[CH2:59]>CO>[CH3:8][C:9]1[CH:46]=[C:45]([CH3:47])[CH:44]=[CH:43][C:10]=1[O:11][CH2:12][C@H:13]([OH:42])[CH2:14][NH:15][C:16]1[CH:21]=[CH:20][NH:19][C:18](=[O:22])[C:17]=1[C:23]1[NH:34][C:33]2[C:25]([N:24]=1)=[CH:26][C:27]1[CH2:28][N:29]([CH:36]3[CH2:37][CH2:38][N:39]([CH2:59][CH2:58][C:57]#[N:60])[CH2:40][CH2:41]3)[C:30](=[O:35])[C:31]=1[CH:32]=2

Participants

6

Reactant 4

HCID 6422Trifluoroacetic acidHCID 7855AcrylonitrileHCID 81531DiisopropylethylamineHCID 1784268602-(4-[(R)-3-(2,4-dimethyl-phenoxy)-2-hydroxy-propylamino]-2-oxo-1,2-dihydro-pyridin-3-yl)-6-piperidin-4-yl-6,7-dihydro-3H-1,3,6-triaza-s-indacen-5-one

Product 1

HCID 178426863HCID 178426863, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
0 °C

Procedure

To a solution of the TFA salt of 2-{4-[(R)-3-(2,4-dimethyl-phenoxy)-2-hydroxy-propylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-6-piperidin-4-yl-6,7-dihydro-3H-1,3,6-triaza-s-indacen-5-one (40 mg, 0.061 mmol) in MeOH (2.4 mL) was added DIEA (600 L, 3.4 mmol) at 0° C. under N2 resulting a mixture which was stirred under N2 at 0° C. for 20 min and followed by addition of acrylonitrile (197 μL, 3.0 mmol) via a syringe. The reaction mixture was stirred under N2 at 0° C. for 1 h and at the room temperature for 1 h and then evaporated. The residue was subjected to HPLC purification to afford the title compound in TFA salt form. 1H NMR (DMSO-d6) δ 1.99-2.13 (4H), 2.19 (s, 3H, CH3), 2.22 (s, 3H, CH3), 3.12 (m, 2H), 3.22 (m, 2H), 3.47 (m, 2H), 3.51-3.75 (4H), 4.01 (m, 2H), 4.13 (m, 1H), 4.34 (m, 1H), 4.47 (s, 2H), 6.22 (d, J=7 Hz, 1H), 6.84 (d, J=7 Hz, 1H), 6.94 (d, J=7 Hz, 1H), 6.96 (s, 1H), 7.36 (d, J=7 Hz, 1H), 7.59 (br s, 1H), 7.86 (br s, 1H), 11.13 (br s, 1H, NH), 11.23 (br d, J=6 Hz, 1H, NH); ESI-MS m/z 596.5 (MH+).

Workup

  1. stirringThe reaction mixture was stirred under N2 at 0° C. for 1 h and at the room temperature for 1 h
  2. customevaporated
  3. customThe residue was subjected to HPLC purification

Sources & evidence

ORD record
ord-6d1096d29f8147e3a98932772e5fbc0d
Source dataset
uspto-grants-2016_03
Patent number
US09290503B2

Reaction notes

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