反应详情

A 4 mL vial was charged with palladium(II) acetate (2.6 mg, 0.012 mmol), 1,4-bis(diphenylphosphino)butane (3.0 mg, 7.03 μmol), and ethanol (0.1 ml). This catalyst mixture was degassed (3×) and stirred under nitrogen for 15 min. Sodium borohydride (3.5 mg, 0.093 mmol) was added to a stirred solution of (3R,3aR,6R,6aR)-6-[1-allyl-6-chloro-5-[4-[5-(2,2,2-trifluoroethyl)-4,6-dihydropyrrolo[3,4-c]pyrazol-2-yl]phenyl]imidazo[4,5-b]pyridin-2-yl]oxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-ol (9.5 mg, 0.016 mmol) in ethanol (0.15 ml) and DCM (0.05 ml). The sodium borohydride mixture was degassed (3×) and placed under nitrogen. The catalyst mixture was transferred via syringe to the sodium borohydride reaction mixture.

1. customThis catalyst mixture was degassed (3×)
2. customThe sodium borohydride mixture was degassed (3×)
3. customThe catalyst mixture was transferred via syringe to the sodium borohydride reaction mixture