反应详情

N-([1,1′-biphenyl]-2-yl)-6-cyclohexyldibenzo[b,d]furan-4-amine (8.3 g. 20.0 mmol), 4-iodoanisole (18.7 g, 80.0 mmol), potassium carbonate (5.5 g, 40.0 mmol), copper powder (1.3 g, 20.0 mmol), and 18-crown-6 ether (5.3 g, 20.0 mmol) were mixed. The resultant mixture was bubbled with nitrogen for 30 min. The mixture was refluxed for 20 h. After cooling, the solvent was removed in vacuo and the residue was purified by flash chromatography using 15% DCM/hexane (containing 1% triethylamine) to yield N-([1,1′-biphenyl]-2-yl)-6-cyclohexyl-N-(4-methoxyphenyl)dibenzo[b,d]furan-4-amine (9.0 g, 86% yield) as a white solid.

1. customThe resultant mixture was bubbled with nitrogen for 30 min
2. temperatureThe mixture was refluxed for 20 h
3. temperatureAfter cooling
4. customthe solvent was removed in vacuo
5. customthe residue was purified by flash chromatography