Phenylacetyl chloride → HCID 86709897, compound

HRID 929491Notes

Reaction equation

HRID 929491 reaction equation
[C:1]1([CH2:7][C:8](Cl)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([NH:18][CH2:19][C:20]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[O:21])=[CH:14][CH:13]=1>C1COCC1>[Cl:11][C:12]1[CH:13]=[CH:14][C:15]([N:18]([CH2:19][C:20](=[O:21])[C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)[C:8](=[O:9])[CH2:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[CH:16][CH:17]=1

Participants

4

Reactant 2

HCID 7679Phenylacetyl chlorideHCID 109558352-(4-Chloroanilino)-1-phenylethan-1-one

Product 1

HCID 86709897HCID 86709897, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

After dissolving compound 12 (2.27 g, 14.7 mmol) in THF, compound 11 (1.5 g, 6.1 mmol) was added thereto. After the agitation for 2 hours at room temperature, three times extractions were carried out with EA and three times washings were carried out with brine. Water was removed by using Na2SO4 and distillation under the reduced pressure was carried out. After the removal of a junk by column chromatography (EA/HX= 1/9), the next reaction was followed as a crude condition.

Workup

  1. additionwas added
  2. extractionthree times extractions
  3. customWater was removed
  4. distillationNa2SO4 and distillation under the reduced pressure
  5. customAfter the removal of a junk by column chromatography (EA/HX= 1/9)
  6. customthe next reaction

Sources & evidence

ORD record
ord-8198fe96bad84e82b6352c0467f837c3
Source dataset
uspto-grants-2016_03
Patent number
US09296690B2

Reaction notes

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