反应详情

After dissolving compound 2 (5.00 g, 36.7 mmol) in ACN (30 ml), compound 10 (7.31 g, 36.7 mmol) and TEA (5.63 ml) were sequentially added thereto. After the agitation for 30 minutes at room temperature, the temperature was reduced to 0° C., DBU (16.5 ml) was dropped and the agitation for 1 hour was carried out. After the termination of the reaction, EA and 1N HCL aqueous solution were added thereto and the organic layer was washed three times with brine. Water was removed by using anhydrous Na2SO4 and the distillation under the reduced pressure was carried out to obtain compound 18.

1. additionwere sequentially added
2. customwas reduced to 0° C.
3. waitthe agitation for 1 hour was carried out
4. additionwere added
5. washthe organic layer was washed three times with brine
6. customWater was removed
7. distillationthe distillation under the reduced pressure