3,5-Dibromosalicylaldehyde → 3,3''-Dichloro-4'-hydroxy-4,4''-bis(trifluoromethyl)-[1,1':3',1''-terphenyl]-5'-carbaldehyde

HRID 929593Notes

Reaction equation

HRID 929593 reaction equation
C(N[CH2:6][C:7]1[C:8]([OH:35])=[C:9]([C:24]2[CH:29]=[CH:28][C:27]([C:30]([F:33])([F:32])[F:31])=[C:26]([Cl:34])[CH:25]=2)[CH:10]=[C:11]([C:13]2[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[C:15]([Cl:23])[CH:14]=2)[CH:12]=1)(C)(C)C.BrC1C=C(Br)C=C(C=[O:41])C=1O.ClC1C=C(B(O)O)C=CC=1C(F)(F)F>>[Cl:23][C:15]1[CH:14]=[C:13]([C:11]2[CH:12]=[C:7]([CH:6]=[O:41])[C:8]([OH:35])=[C:9]([C:24]3[CH:29]=[CH:28][C:27]([C:30]([F:31])([F:33])[F:32])=[C:26]([Cl:34])[CH:25]=3)[CH:10]=2)[CH:18]=[CH:17][C:16]=1[C:19]([F:22])([F:21])[F:20]

Participants

4

Reactant 3

HCID 70243,5-DibromosalicylaldehydeHCID 37729583-Chloro-4-(trifluoromethyl)benzeneboronic acidHCID 867187735'-((tert-Butylamino)methyl)-3,3''-dichloro-4,4''-bis(trifluoromethyl)-[1,1':3',1''-terphenyl]-4'-ol

Product 1

HCID 867187723,3''-Dichloro-4'-hydroxy-4,4''-bis(trifluoromethyl)-[1,1':3',1''-terphenyl]-5'-carbaldehyde

Procedure

3,3″-Dichloro-4′-hydroxy-4,4″-bis(trifluoromethyl)-[1,1′:3′,1″-terphenyl]-5′-carbaldehyde was prepared using the procedure described in Intermediate 5 from 3,5-dibromosalicylaldehyde and 3-chloro-4-(trifluoromethyl)phenylboronic acid.

Sources & evidence

ORD record
ord-5fe43679530b41eb98665fde661530ef
Source dataset
uspto-grants-2016_03
Patent number
US09296696B2

Reaction notes

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