反应详情

3-(4-Hydroxy-phenyl)-isoxazole-5-carboxylic acid amide (which may be prepared as described in Preparation of Intermediate 2; 50 mg, 0.24 mmol), K2CO3 (37 mg, 0.27 mmol) and tetrabutylammonium iodide (9 mg, 0.024 mmol) were taken up in DMF (2.4 mL). 2-Methoxybenzyl chloride (42 mg, 0.27 mmol) was added and the reaction mixture was stirred at room temperature overnight. The solvent was evaporated and the residue was purified by high-throughput purification to give 3-[4-(2-methoxy-benzyloxy)-phenyl]-isoxazole-5-carboxylic acid amide (10.5 mg, 13%). LRMS (ESI+): m/z [M+H]+ 325.0.

1. customThe solvent was evaporated
2. customthe residue was purified by high-throughput purification