反应详情

0.12 ml (0.70 mmol) of N,N-diisopropylethylamine is added to a solution of 220 mg (0.23 mmol, 37% purity) of the compound of Example 64A, 57 mg (0.47 mmol) of 4-imidazolinone-hydrochloride, and 142 mg (0.38 mmol) of HATU in 6 ml of THF, and the mixture that is obtained is stirred for 20 hours at room temperature. After the further addition of 57 mg (0.47 mmol) of 4-imidazolinone-hydrochloride as well as 89 mg (0.23 mmol) of HATU, stirring is continued for 16 hours at 60° C. The crude product is separated by means of preparative HPLC (mobile solvent: acetonitrile/water gradient). 39 mg (35% of theory, 88% purity) of the title compound is obtained.

1. customthe mixture that is obtained
2. stirringstirring
3. waitis continued for 16 hours at 60° C
4. customThe crude product is separated by means of preparative HPLC (mobile solvent: acetonitrile/water gradient)