Hydrochloric Acid → HCID 86732283, compound

HRID 930470Notes

Reaction equation

HRID 930470 reaction equation
[O:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH2:6][O:7][C:8]1[N:9]=[CH:10][C:11]([C:14]([O:16]C)=[O:15])=[N:12][CH:13]=1.[OH-].[Na+].Cl>O1CCOCC1>[O:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH2:6][O:7][C:8]1[N:9]=[CH:10][C:11]([C:14]([OH:16])=[O:15])=[N:12][CH:13]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 86732282HCID 86732282, compound

Product 1

HCID 86732283HCID 86732283, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of methyl 5-(oxazol-2-ylmethoxy)pyrazine-2-carboxylate (0.761 g, 3.23 mmol) in 1,4-dioxane (16.17 mL) was added sodium hydroxide 1.0N solution (3.23 ml, 3.23 mmol) to stir at room temperature for 16 h. Then HCl, 4.0M solution in 1,4-dioxane (1.617 ml, 6.47 mmol,) was added to stir for 10 min. The reaction mixture was concentrated in vacuo. MS m/z=221.9 [M+H]+. Calculated for C9H7N3O4: 221.044

Workup

  1. stirringto stir for 10 min
  2. concentrationThe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-3649cd43072147fc98c429116a296fa6
Source dataset
uspto-grants-2016_03
Patent number
US09296734B2

Reaction notes

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